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The vast majority of people who misuse steroids are male non-athlete weightlifters in their 20s or 30s. 1,22 contrary to popular belief, only about 22 percent of anabolic steroid users started as teenagers. 23 anabolic steroid use is less common among females, since fewer women desire extreme muscularity and the masculinizing effects of steroids. Anabolic steroids work differently from other drugs of abuse; they do not have the same short-term effects on the brain. The most important difference is that steroids do not directly activate the reward system to cause a “high”; they also do not trigger rapid increases in the brain chemical dopamine, which reinforces most other types of drug taking behavior. Anabolic steroids can increase energy, libido, and concentration. However, the withdrawal symptoms of steroids are essentially the opposite of the drug’s effects. When someone stops taking steroids after a long period of time, they may have symptoms of withdrawal such as depression, fatigue, joint pain and anxiety. Androgenic anabolic steroids (aas) are synthetic testosterone derivatives. Testosterone is metabolized by 5-alpha-reductase to dihydrotestosterone (dht). Dht acts in the cell nucleus of target tissues and is primarily responsible for the androgenic (i. , masculinizing) and anabolic (i. Androgenic-anabolic steroids develops a steroid use disorder, the effects of the drugs on the central nervous system and the psyche are still not well understood. Although most addictive substances improve mood immediately after administration, aas exert less pronounced euphoric effects. Instead, they are primarily taken for. [article in japanese] umehara c, sugimoto t. Pmid: 4112471 [indexed for medline]. Anabolic steroids or more precisely, anabolic/androgenic steroids are also referred to as ergogenic or performance-enhancing drugs. They are synthetic derivatives of testosterone, a natural male hormone. The author has published that the compassionate use of an admixture of anabolic steroids has set the worst case of endometriosis into a 9-year remission, and herein, five of six cases of intractable ibd have experienced 5-year reversal of their disabling state of disease. Anabolic-androgenic steroids (aas) are steroidal androgens which include natural androgens such as male sex hormone testosterone or could be synthetic to mimic the action of the endogenous male hormone. Oxandrolone is a synthetic, anabolic steroid hormone analog of testosterone. Similar to testosterone, oxandrolone binds to and activates specific nuclear receptors. This agent may be used for testosterone replacement therapy in hypogonadal men, in hiv-wasting syndrome, and in other conditions in order to increase nitrogen retention and fat-free muscle mass. 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